• Molecular NameParicalcitol
  • Synonymparicalcitol
  • Weight416.646
  • Drugbank_IDDB00910
  • ACS_NO131918-61-1
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)5.52
  • pkaN/A
  • LogD (pH=7, predicted)5.52
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-5.6
  • LogSw (predicted, AB/LogsW2.0)0.02
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors3
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds5
  • TPSA60.69
  • StatusFDA approved
  • AdministrationOral, Intravenous
  • PharmacologyAn analog of calcitriol, the active form of vitamin D. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability72.0
  • Protein binding99.8
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolized by multiple hepatic and non-hepatic enzymes, including mitochondrial CYP24, as well as CYP3A4 and UGT1A4
  • Half life5~7 h
  • ExcretionBiliary
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A