- Molecular NameSpironolactone
- SynonymNA
- Weight416.582
- Drugbank_IDDB00421
- ACS_NO52-01-7
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)2.69
- pkaN/A
- LogD (pH=7, predicted)2.69
- Solubility (experiment)0.0219 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-5.34
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds2
- TPSA85.74
- StatusFDA approved
- AdministrationN/A
- PharmacologyA diuretic and is used as an antiandrogen.
- Absorption_value73.0
- Absorption (description)Fairly rapidly absorbed from the gastrointestinal tract. Food increases the bioavailability of unmetabolized spironolactone by almost 100%.
- Caco_2N/A
- Bioavailability25.0
- Protein binding98.0
- Volume of distribution (VD)10 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmSpironolactone (S) is extensively metabolized; it has three known active metabolites: canrenone (C), 7alpha-thiomethylspirononlactone (TS), and 6beta-hydroxy-7alpha-thiomethylspirononlactone (HTS).
- Half life1.3 h
- ExcretionUrine, bile
- Urinary Excretion<1
- Clerance93 ml/min/kg
- ToxicityThe oral LD50 of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.
- LD50 (rat)N/A
- LD50 (mouse)LD50>1,000 mg/kg