• Molecular NameAlfentanil
  • SynonymAlfentanilum [INN-Latin]; Alfentanyl
  • Weight416.526
  • Drugbank_IDDB00802
  • ACS_NO71195-58-9
  • Show 3D model
  • LogP (experiment)2.16
  • LogP (predicted, AB/LogP v2.0)1.65
  • pka6.5
  • LogD (pH=7, predicted)1.61
  • Solubility (experiment)0.0346 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.33
  • LogSw (predicted, AB/LogsW2.0)1.17
  • Sw (mg/ml) (predicted, ACD/Labs)0.74
  • No.of HBond Donors0
  • No.of HBond Acceptors9
  • No.of Rotatable Bonds9
  • TPSA81.05
  • StatusFDA approved
  • AdministrationIntravenous
  • PharmacologyA potent but short-acting synthetic opioid analgesic drug, used for anaesthesia in surgery.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability1.0
  • Protein binding92.0
  • Volume of distribution (VD)0.5 to 1.0 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)Plasma : whole blood ratio, 1.6.
  • MetabollsmHepatic
  • Half life90~110 min
  • ExcretionN/A
  • Urinary ExcretionN/A
  • ClerancePlasma clearance, about 3 to 8 mL/min/kg.
  • ToxicitySymptoms of overexposure include characteristic rigidity of the skeletal muscles, cardiac and respiratory depression, and narrowing of the pupils.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A