• Molecular NameRamipril
  • SynonymRamiprilum [Latin]
  • Weight416.518
  • Drugbank_IDDB00178
  • ACS_NO87333-19-5
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.26
  • pkaN/A
  • LogD (pH=7, predicted)-1.02
  • Solubility (experiment)3.5 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-0.19
  • LogSw (predicted, AB/LogsW2.0)4.06
  • Sw (mg/ml) (predicted, ACD/Labs)7.69
  • No.of HBond Donors2
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds10
  • TPSA95.94
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn angiotensin-converting enzyme (ACE) inhibitor, used to treat hypertension and congestive heart failure.
  • Absorption_value60.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability44.0
  • Protein binding73.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHydrolyzed to its active metabolite, ramiprilat.
  • Half life5 h
  • ExcretionRenal (60%) and fecal (40%)
  • Urinary Excretion<2
  • Clerance23 ml/min/kg
  • ToxicityThe most likely clinical manifestations would be symptoms attributable to hypotension. LD50 = 10933 mg/kg (orally in mice).
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=10933 mg/kg