• Molecular NameAcemetacin
  • SynonymNA
  • Weight415.829
  • Drugbank_IDN/A
  • ACS_NO53164-05-9
  • Show 3D model
  • LogP (experiment)4.13
  • LogP (predicted, AB/LogP v2.0)3.98
  • pka2.9
  • LogD (pH=7, predicted)1.68
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.87
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.13
  • No.of HBond Donors1
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds7
  • TPSA94.83
  • StatusPOM(UK)
  • AdministrationN/A
  • PharmacologyA non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIt is metabolised to indometacin (major metabolite) and p-chlorobenzoic acid (PCBA, minor metabolite and degradation product) by hydrolysis in the liver.
  • Half life1 h
  • ExcretionThe drug is eliminated by both hepatic and renal routes; the pharmacokinetics are unaffected by moderate renal or hepatic impairment.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A