• Molecular NameMoxifloxacin
  • SynonymBAY 12-8039; moxifloxacin; Moxifloxacin HCl; Moxifloxacin hydrochloride
  • Weight415.465
  • Drugbank_IDDB00218
  • ACS_NO354812-41-2
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)1.02
  • pka6.4; 9.5
  • LogD (pH=7, predicted)-2.34
  • Solubility (experiment)24 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.43
  • LogSw (predicted, AB/LogsW2.0)0.1
  • Sw (mg/ml) (predicted, ACD/Labs)0.13
  • No.of HBond Donors3
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds5
  • TPSA90.9
  • StatusFDA approved
  • AdministrationOral, IV, local (eyedrops)
  • PharmacologyA third generation synthetic fluoroquinolone chemotherapeutic agent developed by Bayer AG (initially called BAY 12-8039).
  • Absorption_value90.0
  • Absorption (description)Well absorbed from the gastrointestinal tract. Absolute oral bioavailability is approximately 90%. Food has little effect on absorption.
  • Caco_2N/A
  • Bioavailability86.0
  • Protein binding39.4
  • Volume of distribution (VD)2.05 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmApproximately 52% of an oral or intravenous dose of moxifloxacin is metabolized via glucuronide and sulfate conjugation. The cytochrome P450 system is not involved in moxifloxacin metabolism, and is not affected by moxifloxacin. The sulfate conjugate (M1) accounts for approximately 38% of the dose, and is eliminated primarily in the feces. Approximately 14% of an oral or intravenous dose is converted to a glucuronide conjugate (M2), which is excreted exclusively in the urine. Peak plasma concentrations of M2 are approximately 40% those of the parent drug, while plasma concentrations of M1 are generally less than 10% those of moxifloxacin.
  • Half life11.5~15.6 h
  • ExcretionApproximately 45% of an oral or intravenous dose of moxifloxacin is excreted as unchanged drug (~20% in urine and ~25% in feces). A total of 96% ± 4% of an oral dose is excreted as either unchanged drug or known metabolites.
  • Urinary Excretion21.9
  • Clerance2.27 ml/min/kg
  • ToxicitySymptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A