• Molecular NameNoscapine
  • SynonymNarcotine; Nectodon; Nospen; Anarcotine
  • Weight413.426
  • Drugbank_IDN/A
  • ACS_NO128-62-1
  • Show 3D model
  • LogP (experiment)2.0
  • LogP (predicted, AB/LogP v2.0)1.5
  • pka6.2
  • LogD (pH=7, predicted)1.42
  • Solubility (experiment)Slightly soluble
  • LogS (predicted, ACD/Labs)(ph=7)-4.27
  • LogSw (predicted, AB/LogsW2.0)0.17
  • Sw (mg/ml) (predicted, ACD/Labs)0.02
  • No.of HBond Donors0
  • No.of HBond Acceptors8
  • No.of Rotatable Bonds4
  • TPSA75.69
  • StatusN/A
  • AdministrationN/A
  • PharmacologyNoscapine is primarily used for its antitussive (cough-suppressing) effects. It has also been shown to have anticancer activity.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability30.0
  • Protein bindingN/A
  • Volume of distribution (VD)3 to 7 L/kg (mean 5)
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life2.5 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityThe side effects which have been observed with very high doses of noscapine have generally been limited to nausea and abdominal discomfort in a small percentage of patients. Extensive toxicology studies carried out in both animals and humans, have confirmed its extremely low toxicity, with little or no effect on vital organs and blood parameters, and with negligible side effects.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A