• Molecular NameClobetasol
  • SynonymNA
  • Weight410.913
  • Drugbank_IDDB01013
  • ACS_NO25122-46-7
  • Show 2D model
  • LogP (experiment)2.48
  • LogP (predicted, AB/LogP v2.0)2.85
  • pkaN/A
  • LogD (pH=7, predicted)2.85
  • Solubility (experiment)0.00386 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-4.72
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors2
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds2
  • TPSA74.6
  • StatusFDA approved
  • AdministrationTopical
  • PharmacologyA corticosteroid used to treat various skin disorders including eczema and psoriasis. Clobetasol belongs to Class I (Super Potent) of the corticosteroids, making it one of the most potent available.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolized, primarily in the liver, and then excreted by the kidneys.
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityTopically applied clobetasol can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
  • LD50 (rat) >3000 mg/kg
  • LD50 (mouse) >3000 mg/kg