- Molecular NameBeclomethasone
- SynonymBeclometasona [INN-Spanish]; Beclometasone; Beclometasonum [INN-Latin]
- Weight408.922
- Drugbank_IDDB00394
- ACS_NO4419-39-0
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)2.29
- pkaN/A
- LogD (pH=7, predicted)2.29
- Solubility (experiment)0.04939 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-4.14
- LogSw (predicted, AB/LogsW2.0)0.04
- Sw (mg/ml) (predicted, ACD/Labs)0.03
- No.of HBond Donors3
- No.of HBond Acceptors5
- No.of Rotatable Bonds2
- TPSA94.83
- StatusFDA approved
- AdministrationN/A
- PharmacologyA synthetic halogenated glucocorticoid with antiinflammatory and vasoconstrictive effects, is used for treating steroid-dependent asthma, allergic or nonallergic rhinitis, or recurrent nasal polyps.
- Absorption_valueN/A
- Absorption (description)N/A
- Caco_2N/A
- BioavailabilityN/A
- Protein binding87.0
- Volume of distribution (VD)Beclometasone dipropionate, median, 20 (range 10.6 to 39.4) L; beclometasone 17-monopropionate, 424 (362 to 496) L.
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmBeclometasone dipropionate is rapidly converted to the metabolite beclometasone-17-monopropionate.
- Half life2.8 hours; 0.3~0.7 h (Beclometasone dipropionate); 1.3~5.3 h (beclometasone 17-monopropionate)
- ExcretionN/A
- Urinary ExcretionN/A
- Clerancebeclometasone dipropionate, median, 150 (98.8 to 228) L/h; beclometasone 17-monopropionate, 120 (104 to 139) L/h.
- ToxicityThe acute toxicity of beclomethasone dipropionate is low. The only harmful effect that follows inhalation of large amounts of the drug over a short period of time is suppression of hypothalamic-pituitary-adrenal (HPA) function. Chronic: The excessive use of beclomethasone dipropionate over a long period could lead to adrenal suppression.
- LD50 (rat)N/A
- LD50 (mouse)N/A