• Molecular NameAlclometasone
  • SynonymAlclometasone dipropionate
  • Weight408.922
  • Drugbank_IDDB00240
  • ACS_NO66734-13-2
  • Show 3D model
  • LogP (experiment)3.669
  • LogP (predicted, AB/LogP v2.0)2.2
  • pkaN/A
  • LogD (pH=7, predicted)2.2
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)-3.99
  • LogSw (predicted, AB/LogsW2.0)0.07
  • Sw (mg/ml) (predicted, ACD/Labs)0.04
  • No.of HBond Donors3
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds2
  • TPSA94.83
  • StatusFDA approved
  • Administrationtopical
  • PharmacologyA synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
  • Absorption_valueN/A
  • Absorption (description)Topical corticosteroids can be absorbed from normal intact skin. Studies have shown that approximately 3% of steroid is absorbed during 8 hours of contact with intact skin of normal volunteers.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic.
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdose include suppression of adrenal glands, temporary decrease in white blood cell counts, symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing), and increased susceptibility to infection.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A