- Molecular NameHexachlorophene
- SynonymNA
- Weight406.907
- Drugbank_IDDB00756
- ACS_NO70-30-4
- Show 3D model
- LogP (experiment)7.54
- LogP (predicted, AB/LogP v2.0)7.45
- pka4.95
- LogD (pH=7, predicted)6.24
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-6.31
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors2
- No.of HBond Acceptors2
- No.of Rotatable Bonds2
- TPSA40.46
- StatusFDA approved
- AdministrationN/A
- PharmacologyA disinfectant.
- Absorption_valueN/A
- Absorption (description)Absorbed after oral administration and through the skin.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding92.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmN/A
- Half lifeN/A
- ExcretionAfter topical application, up to about 10% may be excreted in the urine over a period of 4 to 5 days.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe estimated minimum lethal dose is 5 g. A number of deaths have occurred after accidental ingestion and also after chronic application for the treatment of burns. Repeated exposure of neonates and infants to high concentrations of hexachlorophene has been associated with spongy lesions of the brain. Fatalities have been associated with blood concentrations greater than 2 mg/L, although recovery has occurred after development of plasma concentrations up to 90 mg/L.
- LD50 (rat)LD50 = 66 mg/kg
- LD50 (mouse)N/A