• Molecular NameToremifene
  • Synonymtoremifene
  • Weight405.969
  • Drugbank_IDDB00539
  • ACS_NO89778-26-7
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)6.71
  • pka8.0
  • LogD (pH=7, predicted)5.32
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-3.99
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors0
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds9
  • TPSA12.47
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body.
  • Absorption_value100.0
  • Absorption (description)Well absorbed
  • Caco_2N/A
  • Bioavailability100.0
  • Protein binding99.7
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmToremifene (T) is metabolized by CYP3A to N-desmethyltoremifene (DMT), a metabolite that accumulates in blood and has anti-estrogenic activity. Toremifene appears to undergo enterohepatic recycling, prolonging its apparent t1/2.
  • Half life5 days (toremifene); 6 days (N-desmethyltoremifene)
  • ExcretionN/A
  • Urinary ExcretionNegligible
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A