• Molecular NameBenzquinamide
  • SynonymNA
  • Weight404.507
  • Drugbank_IDDB00767
  • ACS_NO63-12-7
  • Show 3D model
  • LogP (experiment)2.113
  • LogP (predicted, AB/LogP v2.0)2.54
  • pka5.9
  • LogD (pH=7, predicted)2.51
  • Solubility (experiment)0.153 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.35
  • LogSw (predicted, AB/LogsW2.0)0.4
  • Sw (mg/ml) (predicted, ACD/Labs)1.66
  • No.of HBond Donors0
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds7
  • TPSA68.31
  • StatusFDA approved
  • Administrationintramuscular injection
  • PharmacologyAn antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties.
  • Absorption_valueN/A
  • Absorption (description)Readily absorbed after oral administration; bioavailability about 35%. Incomplete, with 33~39% bioavailability via the capsule and suppository routes, relative to the intramuscular route.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)1 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolised by O-demethylation, deacetylation and N-dealkylation.
  • Half life1 h
  • ExcretionAfter an oral dose, up to about 7% is excreted unchanged in the urine in 24 h.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A