• Molecular NameAlfacalcidol
  • Synonym1-hydroxycholecalciferol; 1alpha-hydroxycholecalciferol; 1alpha-hydroxyvitamin D3
  • Weight400.647
  • Drugbank_IDDB01436
  • ACS_NO41294-56-8
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)6.67
  • pkaN/A
  • LogD (pH=7, predicted)6.67
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-6.26
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors2
  • No.of HBond Acceptors2
  • No.of Rotatable Bonds6
  • TPSA40.46
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn analogue of vitamin D.
  • Absorption_value100.0
  • Absorption (description)Alfacalcidol is well absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability71.0
  • Protein binding99.8
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmIt is converted rapidly in the liver to calcitriol
  • Half life3~6 h (calcitriol)
  • ExcretionEliminated via bile and kidneys.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A