- Molecular NameMepacrine
- SynonymAcrichine; Acrinamine; Acriquine; Akrichin; Antimalarina; Atabrine; Atebrin; Atebrine; Erion; Erion Hydrochloride; Haffkinine; Italchine; Quinacrine; Quinactine
- Weight399.966
- Drugbank_IDN/A
- ACS_NO83-89-6
- Show 3D model
- LogP (experiment)5.8
- LogP (predicted, AB/LogP v2.0)6.13
- pka7.7, 10.3
- LogD (pH=7, predicted)1.53
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.41
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.03
- No.of HBond Donors1
- No.of HBond Acceptors4
- No.of Rotatable Bonds9
- TPSA37.39
- StatusN/A
- AdministrationN/A
- PharmacologyA drug with a number of different medical applications.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration; it appears in the blood within 2 h, peak concentrations being attained in 8 h. Mepacrine accumulates in the body during chronic administration and is widely distributed, high concentrations being found in the liver, lungs and spleen; it also persists in the skin and finger-nails.
- Caco_2N/A
- BioavailabilityN/A
- Protein binding85.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)Concentrated in the erythrocytes.
- MetabollsmN/A
- Half life5 days
- ExcretionThe urine and skin may become yellow. It is excreted very slowly in the urine and bile with significant amounts detectable in the urine for at least 2 months after the discontinuation of therapy. Several metabolites are excreted but these account for not more than 5% of the dose.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityLarge doses may give rise to nausea and vomiting and occasionally to transient mental disturbances. Attempts at suicide with massive doses have not been successful.
- LD50 (rat)N/A
- LD50 (mouse)N/A