- Molecular NameS-Adenosylmethionine
- SynonymAdoMet; S-Adenosyl-L-methionine; SAM; SAM-e
- Weight399.452
- Drugbank_IDDB00118
- ACS_NO29908-03-0
- Show 2D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)-6.61
- pkaN/A
- LogD (pH=7, predicted)-6.97
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)N/A
- LogSw (predicted, AB/LogsW2.0)177.1
- Sw (mg/ml) (predicted, ACD/Labs)N/A
- No.of HBond Donors7
- No.of HBond Acceptors11
- No.of Rotatable Bonds7
- TPSA182.63
- StatusFDA approved
- AdministrationN/A
- PharmacologyIt possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.
- Absorption_valueN/A
- Absorption (description)S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake.
- Caco_2N/A
- Bioavailability5.0
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmSignificant first-pass metabolism in the liver. Approximately 50% of S-Adenosylmethionine (SAMe) is metabolized in the liver. SAMe is metabolized to S-adenosylhomocysteine, which is then metabolized to homocysteine. Homocysteine can either be metabolized to cystathionine and then cysteine or to methionine. The cofactor in the metabolism of homocysteine to cysteine is vitamin B6. Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and betaine.
- Half lifeN/A
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityIrritating to mucus membranes and upper respiratory tract. Can cause CNS depression.
- LD50 (rat)N/A
- LD50 (mouse)N/A