- Molecular NameColchicine
- SynonymColchicin; Colchicina; Colchicinum
- Weight399.443
- Drugbank_IDDB01394
- ACS_NO64-86-8
- Show 3D model
- LogP (experiment)1.03
- LogP (predicted, AB/LogP v2.0)1.07
- pka12.35
- LogD (pH=7, predicted)1.07
- Solubility (experiment)45.9 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.27
- LogSw (predicted, AB/LogsW2.0)1.43
- Sw (mg/ml) (predicted, ACD/Labs)0.21
- No.of HBond Donors1
- No.of HBond Acceptors7
- No.of Rotatable Bonds5
- TPSA83.09
- StatusFDA approved
- AdministrationN/A
- PharmacologyA toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (Autumn crocus, Colchicum autumnale, also known as "Meadow saffron"). It was used originally to treat rheumatic complaints, especially gout, and still finds use for these purposes today. It was also prescribed for its cathartic and emetic effects. Colchicine's present medicinal use is in the treatment of gout and familial Mediterranean fever; it can also be used as initial treatment for pericarditis and preventing recurrences of the condition. It is also being investigated for its use as an anti-cancer drug. In neurons, axoplasmic transport is disrupted by colchicine.
- Absorption_valueN/A
- Absorption (description)Readily absorbed after oral administration with peak plasma concentrations reached within 2 h.
- Caco_2N/A
- Bioavailability50.0
- Protein binding40.0
- Volume of distribution (VD)5.2
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is partially deacetylated in the liver to desmethylcolchicine.
- Half lifeElimination half-life is approximately 1 hour in healthy subjects, although a study with an extended sampling time reported mean terminal elimination half-life values of approximately 9 to 10.5 hours. Other studies have reported half-life values of approximately 2 hours in patients with alcoholic cirrhosis and approximately 2.5 hours in patients with familial Mediterranean fever.
- ExcretionMost of the drug is excreted in the faeces but 10 to 20% is excreted in the urine. Colchicine is excreted in the bile and undergoes enterohepatic circulation. Colchicine is distributed in the kidney, liver, and spleen, but little is found in the heart, skeletal muscle, and brain.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityThe minimum lethal dose in man is about 6 mg although recovery has occurred after much larger doses.
- LD50 (rat)N/A
- LD50 (mouse)LD50=3.5 (ip); LD50=13.5 (po)