• Molecular NameDrotaverine
  • Synonymdrotaverin
  • Weight397.515
  • Drugbank_IDN/A
  • ACS_NO985-12-6
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.92
  • pkaN/A
  • LogD (pH=7, predicted)1.64
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-6.01
  • LogSw (predicted, AB/LogsW2.0)0.01
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors1
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds9
  • TPSA48.95
  • StatusN/A
  • AdministrationOral, intravenous
  • PharmacologyAn antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability58.0
  • Protein binding87.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life7~12 h
  • ExcretionFecal and renal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A