- Molecular NameErgocalciferol
- SynonymSynthetic Vitamin D; Vitamin D2
- Weight396.659
- Drugbank_IDDB00153
- ACS_NO50-14-6
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)7.5
- pkaN/A
- LogD (pH=7, predicted)7.5
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-6.78
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors1
- No.of HBond Acceptors1
- No.of Rotatable Bonds5
- TPSA20.23
- StatusFDA approved
- AdministrationN/A
- PharmacologyA form of vitamin D, also called vitamin D2.
- Absorption_valueN/A
- Absorption (description)Well absorbed after oral administration; absorption may be decreased with impaired liver and biliary function
- Caco_2N/A
- BioavailabilityN/A
- Protein binding99.8
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmExtensive enterohepatic circulation occurs. Metabolised by 25-hydroxylation in the liver followed by 1α- or 24-hydroxylation in the kidney; possibly conjugated with glucuronic acid or sulfate.
- Half life19~48 h (however, stored in fat deposits in body for prolonged periods).
- ExcretionExcreted mainly in the bile together with small amounts of metabolites in the urine; unchanged ergocalciferol does not appear to be excreted in the urine.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityNausea, vomiting and diarrhea, weight loss, irritability, weakness, fatigue, lassitude, and headache.
- LD50 (rat)LD50 = 10 mg/kg
- LD50 (mouse)LD50 = 23.7 mg/kg