• Molecular NameDextromoramide
  • SynonymNA
  • Weight392.543
  • Drugbank_IDN/A
  • ACS_NO357-56-2
  • Show 2D model
  • LogP (experiment)3.61
  • LogP (predicted, AB/LogP v2.0)3.88
  • pkaN/A
  • LogD (pH=7, predicted)3.58
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)-3.62
  • LogSw (predicted, AB/LogsW2.0)0.1
  • Sw (mg/ml) (predicted, ACD/Labs)0.06
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds6
  • TPSA32.78
  • StatusN/A
  • AdministrationOral, Intravenous, Insufflation
  • PharmacologyA powerful opioid analgesic approximately three times more potent than morphine but shorter acting.
  • Absorption_value100.0
  • Absorption (description)Absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability99.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMetabolic reactions may include N-oxidation, hydroxylation, and amide hydrolysis; it is possible that 2-hydroxydextromoramide is a major metabolite.
  • Half life1.5~4.7 h
  • ExcretionExcreted in the urine, partly as unchanged drug.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityThe estimated minimum lethal dose is 500 mg. Fatalities have occurred at blood concentrations greater than 0.04 mg/L.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A