• Molecular NameEszopiclone
  • SynonymEsopiclone
  • Weight388.815
  • Drugbank_IDDB00402
  • ACS_NO138729-47-2
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)0.79
  • pkaN/A
  • LogD (pH=7, predicted)0.58
  • Solubility (experiment)Slightly soluble
  • LogS (predicted, ACD/Labs)(ph=7)-2.58
  • LogSw (predicted, AB/LogsW2.0)22.35
  • Sw (mg/ml) (predicted, ACD/Labs)0.68
  • No.of HBond Donors0
  • No.of HBond Acceptors9
  • No.of Rotatable Bonds3
  • TPSA91.76
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA nonbenzodiazepine hypnotic agent (viz., a sedative) used as a treatment for insomnia. Eszopiclone is the active dextrorotatory stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrolones.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed following oral administration
  • Caco_2N/A
  • Bioavailability75.0
  • Protein binding55.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic oxidation and demethylation (CYP3A4 and CYP2E1-mediated)
  • Half life6 h
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySide effects include viral infection, dry mouth, dizziness, hallucinations, infection, rash, and unpleasant taste, with this relationship clearest for unpleasant taste depending on doses.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A