• Molecular NameTrimethobenzamide
  • SynonymTrimethobenzamide HCL; Trimethobenzamide hydrochloride; Trimethobenzamidum [INN-Latin]; Trimetobenzamida [INN-Spanish]
  • Weight388.464
  • Drugbank_IDDB00662
  • ACS_NO138-56-7
  • Show 2D model
  • LogP (experiment)2.3
  • LogP (predicted, AB/LogP v2.0)2.16
  • pka8.8
  • LogD (pH=7, predicted)0.77
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.97
  • LogSw (predicted, AB/LogsW2.0)0.48
  • Sw (mg/ml) (predicted, ACD/Labs)1.03
  • No.of HBond Donors1
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds10
  • TPSA69.26
  • StatusFDA approved
  • AdministrationOral, rectal, intramuscular
  • PharmacologyAn antiemetic used to prevent nausea and vomiting. It is often prescribed for patients with gastroenteritis, medication-induced nausea, and other illnesses.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability80.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half life7~9 h
  • ExcretionUrine (30% to 50%, as unchanged drug)
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityOral LD50 in mice is 1600 mg/kg.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A