• Molecular NameQuetiapine
  • SynonymQuetiapine fumarate; Quetiapine hemifumarate
  • Weight383.516
  • Drugbank_IDDB01224
  • ACS_NO111974-69-7
  • Show 3D model
  • LogP (experiment)2.296
  • LogP (predicted, AB/LogP v2.0)2.78
  • pka13.3; 6.8
  • LogD (pH=7, predicted)2.77
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-3.38
  • LogSw (predicted, AB/LogsW2.0)0.18
  • Sw (mg/ml) (predicted, ACD/Labs)0.1
  • No.of HBond Donors1
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds6
  • TPSA73.6
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn atypical antipsychotic used in the management of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression, and used off-label for a variety of other purposes, including insomnia and anxiety disorders.
  • Absorption_value73.0
  • Absorption (description)Rapidly and well absorbed.
  • Caco_2N/A
  • Bioavailability9.0
  • Protein binding83.0
  • Volume of distribution (VD)10 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmExtensively metabolized through multiple pathways, including sulfoxidation, N- and O-dealkylation catalyzed by CYP3A4. Two minor active metabolites.
  • Half life6 h
  • ExcretionRenal
  • Urinary Excretion<1
  • Clerance19 ml/min/kg
  • ToxicitySymptoms of overdose include drowsiness and sedation, tachycardia, and hypotension.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A