• Molecular NameDiacetylmorphine
  • SynonymHeroin; diamorphine; Smack
  • Weight383.444
  • Drugbank_IDN/A
  • ACS_NO561-27-3
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)3.25
  • pka7.6
  • LogD (pH=7, predicted)1.79
  • Solubility (experiment)0.588 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.4
  • LogSw (predicted, AB/LogsW2.0)0.14
  • Sw (mg/ml) (predicted, ACD/Labs)0.07
  • No.of HBond Donors0
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds4
  • TPSA65.07
  • StatusN/A
  • AdministrationInhalation, Transmucosal, Intravenous, Oral, Intranasal, Rectal, Intramuscular
  • PharmacologyHeroin is a mu-opioid agonist. It acts on endogenous mu-opioid receptors that are spread in discrete packets throughout the brain, spinal cord and gut in almost all mammals.
  • Absorption_value100.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability1.0
  • Protein binding0.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life2~3 h
  • Excretion90% renal as glucuronides, rest biliary
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A