• Molecular NameTicarcillin
  • SynonymTicarcilina [inn-spanish]; Ticarcillin supplement; Ticarcilline [inn-french]; Ticarcillinum [inn-latin]
  • Weight383.425
  • Drugbank_IDDB01607
  • ACS_NO34787-01-4
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)0.23
  • pka2.7
  • LogD (pH=7, predicted)-4.76
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)0.41
  • LogSw (predicted, AB/LogsW2.0)389.79
  • Sw (mg/ml) (predicted, ACD/Labs)0.31
  • No.of HBond Donors4
  • No.of HBond Acceptors8
  • No.of Rotatable Bonds5
  • TPSA180.71
  • StatusFDA approved
  • AdministrationIntravenous
  • PharmacologyA drug is used in combination with clavulanate as Timentin. Because it is a penicillin, it also falls within the larger class of beta-lactam antibiotics. Its main clinical use is as an injectable antibiotic for the treatment of gram-negative bacteria, in particular, Pseudomonas aeruginosa.
  • Absorption_value0.0
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability0.0
  • Protein binding45.0
  • Volume of distribution (VD)0.16 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmTicarcillin is excreted unchanged in high concentrations in the urine.
  • Half life1.1 h
  • ExcretionRenal
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityAs with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A