• Molecular NameMisoprostol
  • SynonymMisoprostolum [INN-Latin]
  • Weight382.541
  • Drugbank_IDDB00929
  • ACS_NO59122-46-2
  • Show 3D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)4.35
  • pkaN/A
  • LogD (pH=7, predicted)4.35
  • Solubility (experiment)0.401 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.6
  • LogSw (predicted, AB/LogsW2.0)0.23
  • Sw (mg/ml) (predicted, ACD/Labs)0.1
  • No.of HBond Donors2
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds14
  • TPSA83.83
  • StatusFDA approved
  • AdministrationOral, Vaginal, Sublingual
  • PharmacologyA drug that is used for the prevention of non-steroidal anti-inflammatory drug (NSAID)-induced gastric ulcers, for early abortion, to treat missed miscarriage, and to induce labor.
  • Absorption_value88.0
  • Absorption (description)Extensively absorbed
  • Caco_2N/A
  • Bioavailability80.0
  • Protein binding85.0
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmDe-esterified to misoprostol acid, then to prostaglandin F analogs
  • Half lifeMisoprostol, less than 30 min; misoprostol acid, 20 min.
  • ExcretionRenal:80%, Fecal:15%
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityMisoprostol may cause mild to moderate diarrhea, stomach cramps, and/or nausea. less serious side effects are vomiting, flatulence, constipation, headache, and menstrual cramps, spotting, or increased or irregular menstruation.
  • LD50 (rat)N/A
  • LD50 (mouse)N/A