• Molecular NameEconazole
  • SynonymNA
  • Weight381.69
  • Drugbank_IDDB01127
  • ACS_NO27220-47-9
  • Show 3D model
  • LogP (experiment)5.401
  • LogP (predicted, AB/LogP v2.0)5.49
  • pkaN/A
  • LogD (pH=7, predicted)5.38
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-4.85
  • LogSw (predicted, AB/LogsW2.0)0.0
  • Sw (mg/ml) (predicted, ACD/Labs)0.0
  • No.of HBond Donors0
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds6
  • TPSA27.05
  • StatusFDA approved
  • AdministrationCutaneous
  • PharmacologyAn antifungal medication of the imidazole class. It is used as a cream under the brand names Spectazole (US),
  • Absorption_valueN/A
  • Absorption (description)About 10% of a topical dose is absorbed and after vaginal application about 5% of the dose is absorbed.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic
  • Half lifeN/A
  • ExcretionFollowing oral administration, about 40% of the dose is excreted in the urine and 30% is eliminated in the faeces, in 5 days.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)668 mg/kg
  • LD50 (mouse)462 mg/kg