• Molecular NameTrichlormethiazide
  • SynonymNA
  • Weight380.66
  • Drugbank_IDDB01021
  • ACS_NO133-67-5
  • Show 2D model
  • LogP (experiment)0.6
  • LogP (predicted, AB/LogP v2.0)0.75
  • pka8.6
  • LogD (pH=7, predicted)0.46
  • Solubility (experiment)0.795 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-2.84
  • LogSw (predicted, AB/LogsW2.0)0.17
  • Sw (mg/ml) (predicted, ACD/Labs)0.34
  • No.of HBond Donors4
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds2
  • TPSA135.12
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • Bioavailability60.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmN/A
  • Half life2 h
  • ExcretionPrimarily excreted unchanged in urine
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityOral Rat LD50 = 5600 mg/kg, oral Mouse LD50 = 2600 mg/kg
  • LD50 (rat)N/A
  • LD50 (mouse)N/A