- Molecular NameBopindolol
- SynonymNA
- Weight380.488
- Drugbank_IDN/A
- ACS_NO62658-63-3
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)4.31
- pkaN/A
- LogD (pH=7, predicted)2.23
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.24
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.02
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds9
- TPSA63.35
- StatusN/A
- AdministrationN/A
- PharmacologyA beta blocker. It is an ester which acts as a prodrug for pindolol.
- Absorption_valueN/A
- Absorption (description)Bopindolol is rapidly hydrolysed in plasma and no measurable amounts of the parent drug can be detected after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)Mean, 202 L (range, 102 to 504 L) after oral administration; 148 L intravenously
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmThe two main metabolites identified are benzoic acid and an active hydrolysed metabolite.
- Half life4.4 h
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceAfter single dose administration, plasma clearance is 30.9 L/h and for multiple dosing, 38.0 L/h.
- Toxicity Toxicity of the compound was determined after intravenous administration to mice in experiment, LD50=17
- LD50 (rat)N/A
- LD50 (mouse)N/A