- Molecular NameCeliprolol
- SynonymNA
- Weight379.501
- Drugbank_IDN/A
- ACS_NO56980-93-9
- Show 3D model
- LogP (experiment)1.92
- LogP (predicted, AB/LogP v2.0)2.17
- pka9.68
- LogD (pH=7, predicted)-0.31
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-0.61
- LogSw (predicted, AB/LogsW2.0)2.45
- Sw (mg/ml) (predicted, ACD/Labs)0.38
- No.of HBond Donors3
- No.of HBond Acceptors7
- No.of Rotatable Bonds10
- TPSA90.9
- StatusN/A
- AdministrationN/A
- PharmacologyA medication in the class of beta blockers, used in the treatment of high blood pressure.
- Absorption_value50.0
- Absorption (description)Absorbed after oral administration in a non-linear fashion; the percentage of dose absorbed increases with increasing dose.
- Caco_2N/A
- Bioavailability40.0
- Protein binding25.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmUndergoes only minimal metabolism
- Half life5~6 h
- Excretionexcreted unchanged in the urine (approx. 11%) and faeces (84% in 24 h after an oral dose). After an intravenous dose, approx. 50% is excreted in urine and 31% in faeces. A very low percentage of the drug is excreted as three metabolites.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A