• Molecular NameDroperidol
  • SynonymNA
  • Weight379.435
  • Drugbank_IDDB00450
  • ACS_NO548-73-2
  • Show 3D model
  • LogP (experiment)3.5
  • LogP (predicted, AB/LogP v2.0)3.6
  • pka7.46
  • LogD (pH=7, predicted)2.56
  • Solubility (experiment)Insoluble
  • LogS (predicted, ACD/Labs)(ph=7)-3.96
  • LogSw (predicted, AB/LogsW2.0)0.04
  • Sw (mg/ml) (predicted, ACD/Labs)0.01
  • No.of HBond Donors1
  • No.of HBond Acceptors5
  • No.of Rotatable Bonds6
  • TPSA52.65
  • StatusFDA approved
  • Administrationntraveneous, Intramuscular
  • PharmacologyAn antidopaminergic drug used as an antiemetic and antipsychotic. Droperidol is also often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment.
  • Absorption_valueN/A
  • Absorption (description)Absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability75.0
  • Protein binding87.5
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmHepatic; Extensively metabolized.
  • Half life2~3 h
  • ExcretionAbout 75% of a dose is excreted in the urine with less than 10% as unchanged drug; about 22% of a dose is eliminated in the faeces.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)intravenous LD50 of droperidol is 20-43 mg/kg