• Molecular NameDoxapram
  • SynonymNA
  • Weight378.516
  • Drugbank_IDDB00561
  • ACS_NO309-29-5
  • Show 3D model
  • LogP (experiment)3.938
  • LogP (predicted, AB/LogP v2.0)3.95
  • pkaN/A
  • LogD (pH=7, predicted)3.3
  • Solubility (experiment)Sparingly soluble
  • LogS (predicted, ACD/Labs)(ph=7)-2.78
  • LogSw (predicted, AB/LogsW2.0)0.26
  • Sw (mg/ml) (predicted, ACD/Labs)0.21
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds6
  • TPSA32.78
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA respiratory stimulant. Administered intravenously, doxapram stimulates an increase in tidal volume, and respiratory rate.
  • Absorption_valueN/A
  • Absorption (description)Readily absorbed after oral administration.
  • Caco_2N/A
  • Bioavailability64.0
  • Protein bindingN/A
  • Volume of distribution (VD)3 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmThe major metabolite is the 2-ketomorpholino derivative.
  • Half life7 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • Clerance5 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)75 mg/kg (Intravenous)
  • LD50 (mouse)Intravenous