• Molecular NameMefloquine
  • SynonymMefloquine HCL; Mefloquinone
  • Weight378.316
  • Drugbank_IDDB00358
  • ACS_NO53230-10-7
  • Show 3D model
  • LogP (experiment)3.811
  • LogP (predicted, AB/LogP v2.0)3.7
  • pkaN/A
  • LogD (pH=7, predicted)1.62
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.26
  • LogSw (predicted, AB/LogsW2.0)0.03
  • Sw (mg/ml) (predicted, ACD/Labs)0.21
  • No.of HBond Donors2
  • No.of HBond Acceptors3
  • No.of Rotatable Bonds4
  • TPSA45.15
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn orally administered antimalarial drug used prophylactically against and as a treatment for malaria.
  • Absorption_value78.0
  • Absorption (description)Well absorbed from the gastrointestinal tract. The presence of food significantly enhances the rate and extent of absorption.
  • Caco_2N/A
  • Bioavailability80.0
  • Protein binding98.2
  • Volume of distribution (VD)19 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmExtensively hepatic; main metabolite is inactive
  • Half life20 days
  • Excretion Primarily bile and feces; urine (9% as unchanged drug, 4% as primary metabolite
  • Urinary Excretion<1
  • Clerance0.43 ml/min/kg
  • ToxicitySymptoms of overdose include nausea, vomiting, and weight loss.
  • LD50 (rat)LD50=880 mg/kg
  • LD50 (mouse)N/A