- Molecular NameDesoximetasone
- SynonymNA
- Weight376.468
- Drugbank_IDDB00547
- ACS_NO382-67-2
- Show 3D model
- LogP (experiment)2.35
- LogP (predicted, AB/LogP v2.0)2.7
- pkaN/A
- LogD (pH=7, predicted)2.7
- Solubility (experiment)Insoluble
- LogS (predicted, ACD/Labs)(ph=7)-4.01
- LogSw (predicted, AB/LogsW2.0)0.02
- Sw (mg/ml) (predicted, ACD/Labs)0.04
- No.of HBond Donors2
- No.of HBond Acceptors4
- No.of Rotatable Bonds2
- TPSA74.6
- StatusFDA approved
- AdministrationCutaneous
- PharmacologyA medication belonging to the family of medications known as topical corticosteroids. It is used for the relief of various skin conditions, including rashes. It helps to reduce redness, itching, and irritation. Desoximetasone is a synthetic corticosteroid, a class of primarily synthetic steroids used as anti-inflammatory and anti-pruritic agents.
- Absorption_valueN/A
- Absorption (description)Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMetabolized, primarily in the liver, and then excreted by the kidneys.
- Half lifeThe half-life of the material was 15 ± 2 hours (for urine) and 17 ± 2 hours (for feces) between the third and fifth trial day.
- ExcretionN/A
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityTopically applied desoximetasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
- LD50 (rat)N/A
- LD50 (mouse)N/A