• Molecular NameRemifentanil
  • SynonymRemifentanyl
  • Weight376.453
  • Drugbank_IDDB00899
  • ACS_NO132875-61-7
  • Show 2D model
  • LogP (experiment)1.848
  • LogP (predicted, AB/LogP v2.0)1.98
  • pka7.1
  • LogD (pH=7, predicted)1.8
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.83
  • LogSw (predicted, AB/LogsW2.0)1.88
  • Sw (mg/ml) (predicted, ACD/Labs)4.49
  • No.of HBond Donors0
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds9
  • TPSA76.15
  • StatusFDA approved
  • AdministrationIntravenous
  • PharmacologyA potent ultra short-acting synthetic opioid analgesic drug. It is given to patients during surgery to relieve pain and as an adjunct to an anaesthetic. Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding70.0
  • Volume of distribution (VD)0.3~0.4 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmCleaved by non-specific plasma and tissue esterases
  • Half life0.13~0.33 h
  • ExcretionN/A
  • Urinary ExcretionNegligible
  • Clerance40~60 ml/min/kg
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A