- Molecular NameHydroxyzine
- SynonymHidroxizina [INN-Spanish]; Hydroksyzyny [Polish]; Hydroxine; Hydroxizine; Hydroxizinum; Hydroxycine; Hydroxyzin; Hydroxyzine Base; Hydroxyzine Hcl; Hydroxyzine Pamoate; Hydroxyzinum [INN-Latin]; Hydroxyzyne; Idrossizina [Dcit]
- Weight374.912
- Drugbank_IDDB00557
- ACS_NO68-88-2
- Show 2D model
- LogP (experiment)3.5
- LogP (predicted, AB/LogP v2.0)3.27
- pka2.1, 7.1
- LogD (pH=7, predicted)2.94
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-1.79
- LogSw (predicted, AB/LogsW2.0)0.62
- Sw (mg/ml) (predicted, ACD/Labs)4.07
- No.of HBond Donors1
- No.of HBond Acceptors4
- No.of Rotatable Bonds8
- TPSA35.94
- StatusFDA approved
- AdministrationOral, intramuscular injection
- PharmacologyA first-generation antihistamine of the piperazine class that is an H1 receptor antagonist.
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed from the gastrointestinal tract
- Caco_2N/A
- Bioavailability80.0
- Protein binding93.0
- Volume of distribution (VD)16 L/kg (adult) and 19 L/kg (children)
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHydroxyzine is metabolized to an active metabolite, cetirizine. Plasma concentrations of cetirizine exceed those of parent drug
- Half life20 h (adult) and 7.1 (children)
- ExcretionUrine, Feces
- Urinary ExcretionN/A
- Clerance9.8 ml/min/kg (adult) and 32 ml/min/kg (children)
- ToxicityA plasma concentration of 102.7 mg/L was reported 8.5 h after the ingestion of about 500 mg of hydroxyzine by a 13-month-old child; the child recovered within 72 h. [B. E. Magera,Pediatrics,1981, 67, 280–283.]
- LD50 (rat)LD50=950 mg/kg
- LD50 (mouse)N/A