- Molecular NameProchlorperazine
- SynonymChlormeprazine; Chlorperazine; Prochloroperazine; Prochlorpemazine; Prochlorperazin; Prochlorperazine edisylate; Prochlorperazine maleate; Prochlorpromazine; Procloperazine; Proclorperazine
- Weight373.952
- Drugbank_IDDB00433
- ACS_NO58-38-8
- Show 3D model
- LogP (experiment)4.79
- LogP (predicted, AB/LogP v2.0)4.83
- pka8.1
- LogD (pH=7, predicted)3.65
- Solubility (experiment)0.014 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.75
- LogSw (predicted, AB/LogsW2.0)0.01
- Sw (mg/ml) (predicted, ACD/Labs)0.01
- No.of HBond Donors0
- No.of HBond Acceptors3
- No.of Rotatable Bonds4
- TPSA35.02
- StatusFDA approved
- AdministrationOral, buccal, rectal, IM
- PharmacologyA drug that belongs to the phenothiazine class of antipsychotic agents that are used for the antiemetic treatment of nausea and vertigo. It is also a highly-potent typical antipsychotic, 10 to 20 times more potent than chlorpromazine.
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed following oral administration
- Caco_2N/A
- Bioavailability15.0
- Protein binding95.0
- Volume of distribution (VD)23 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmMainly hepatic (CYP2D6 and/or CYP3A4)
- Half life4~8 h, differs with the mode of application
- ExcretionBiliary, (colored) inactive metabolites in urine
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of central nervous system depression to the point of somnolence or coma. Agitation and restlessness may also occur. Other possible manifestations include convulsions, EKG changes and cardiac arrhythmias, fever and autonomic reactions such as hypotension, dry mouth and ileus; LD50=400mg/kg (orally in mice)
- LD50 (rat)N/A
- LD50 (mouse)LD50=400mg/kg