- Molecular NameKetazolam
- SynonymNA
- Weight368.82
- Drugbank_IDDB01587
- ACS_NO27223-35-4
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)2.76
- pkaN/A
- LogD (pH=7, predicted)2.76
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-5.07
- LogSw (predicted, AB/LogsW2.0)0.02
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors0
- No.of HBond Acceptors5
- No.of Rotatable Bonds1
- TPSA49.85
- StatusFDA approved
- AdministrationN/A
- PharmacologyA drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
- Absorption_value100.0
- Absorption (description)Readily absorbed after oral administration.
- Caco_2N/A
- BioavailabilityN/A
- Protein bindingN/A
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmRapidly metabolised by N-demethylation to desmethylketazolam and desmethyldiazepam (nordazepam).
- Half lifeketazolam about 1.5 h, oxazepam 4 to 25 h (mean 8), diazepam 20 to 100 h (mean 48).
- ExcretionAbout 80% of a dose is excreted in the urine as metabolites with only traces of unchanged drug. Of the material excreted in the urine, about 56% is oxazepam and the remainder is a mixture of minor metabolites including diazepam, desmethyldiazepam, temazepam, and other unidentified metabolites. About 20% of a dose is eliminated in the faeces, mainly as metabolites.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicityOverdoses of up to 0.5 g have been ingested without serious toxic effects.
- LD50 (rat)N/A
- LD50 (mouse)N/A