• Molecular NamePropantheline
  • SynonymPropantheline Bromide; Propanthelinium; Propanthelinum
  • Weight368.497
  • Drugbank_IDDB00782
  • ACS_NO298-50-0
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)0.28
  • pkaN/A
  • LogD (pH=7, predicted)0.28
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-0.35
  • LogSw (predicted, AB/LogsW2.0)2.49
  • Sw (mg/ml) (predicted, ACD/Labs)164.86
  • No.of HBond Donors0
  • No.of HBond Acceptors4
  • No.of Rotatable Bonds7
  • TPSA35.53
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyAn antimuscarinic agent used for the treatment of excessive sweating (hyperhidrosis), cramps or spasms of the stomach, intestines (gut) or bladder, and involuntary urination (enuresis). It can also be used to control the symptoms of irritable bowel syndrome and similar conditions.
  • Absorption_valueN/A
  • Absorption (description)N/A
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmPropantheline is extensively metabolised in the gut and/or liver to xanthanoic acid and its glucuronide and diisopropylmethyl ethanolamine, and to a lesser extent, to hydroxypropantheline, hydroxyxantanoic acid and its glucuronide. A small proportion of propantheline is excret ed in the urine as unchanged parent compound (mean 1.1–5.7% after oral administration, 17.3% after intravenous administration.
  • Half life1~3 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)LD50=85 mg/kg (intraperitoneal)