- Molecular NameCefaclor
- SynonymCCL; Cefaclor anhydrous; Cefaclorum [INN-Latin]; Cephaclor
- Weight367.813
- Drugbank_IDDB00833
- ACS_NO53994-73-3
- Show 2D model
- LogP (experiment)-1.79
- LogP (predicted, AB/LogP v2.0)-0.9
- pka2.43; 7.16
- LogD (pH=7, predicted)-3.56
- Solubility (experiment)8.6 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-1.9
- LogSw (predicted, AB/LogsW2.0)4.85
- Sw (mg/ml) (predicted, ACD/Labs)1.64
- No.of HBond Donors4
- No.of HBond Acceptors7
- No.of Rotatable Bonds4
- TPSA138.03
- StatusFDA approved
- AdministrationN/A
- PharmacologyA second-generation cephalosporin antibiotic used to treat certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections.
- Absorption_valueN/A
- Absorption (description)Cefaclor is well absorbed after oral administration; food may delay absorption but the total amount absorbed is unchanged.
- Caco_2N/A
- Bioavailability90.0
- Protein binding25.0
- Volume of distribution (VD)N/A
- Blood/Plasma Partitioning ratio (D_blood)N/A
- Metabollsm15% to 40%
- Half life0.6~0.9 h
- ExcretionCefaclor is rapidly excreted by the kidneys; up to 85% of a dose appears unchanged in urine within 8 h, with the greater proportion appearing in the first 2 h. Probenecid delays excretion. Some cefaclor is removed by haemodialysis.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySymptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.
- LD50 (rat)N/A
- LD50 (mouse)N/A