- Molecular NameBambuterol
- SynonymBambuterol hydrochloride
- Weight367.446
- Drugbank_IDDB01408
- ACS_NO81732-65-2
- Show 3D model
- LogP (experiment)N/A
- LogP (predicted, AB/LogP v2.0)1.37
- pkaN/A
- LogD (pH=7, predicted)-1.12
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)0.43
- LogSw (predicted, AB/LogsW2.0)19.58
- Sw (mg/ml) (predicted, ACD/Labs)262.92
- No.of HBond Donors2
- No.of HBond Acceptors8
- No.of Rotatable Bonds8
- TPSA91.34
- StatusFDA approved
- AdministrationN/A
- PharmacologyA long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.
- Absorption_value20.0
- Absorption (description)About 20% of a dose is absorbed after oral administration.
- Caco_2N/A
- Bioavailability15.0
- Protein binding45.0
- Volume of distribution (VD)Women, between 1.6 and 2.1 L/kg; men, 1.2 to 1.4 L/kg
- Blood/Plasma Partitioning ratio (D_blood)Distributes extensively outside the plasma component.
- MetabollsmIt concentrates in lung tissue where it is hydrolysed primarily by a plasma cholinesterase to its active metabolite terbutaline (β2 adrenergic receptor agonist). It is also metabolised by oxidative enzymes in the liver. Approximately one-third of an intravenous dose is converted to terbutaline. It also undergoes oxidative metabolism to products that are then metabolised to terbutaline.
- Half life12 h (oral administration); 2.6 h (intravenous administration)
- ExcretionVery little bambuterol is excreted unchanged in urine.
- Urinary ExcretionN/A
- Clerance1250 ml/min
- ToxicityA single oral dose of balsalazide disodium at 5 grams/kg or 4-aminobenzoyl-(beta)-alanine, a metabolite of balsalazide disodium, at 1 gram/kg was non-lethal in mice and rats. No symptoms of acute toxicity were seen at these doses.
- LD50 (rat)N/A
- LD50 (mouse)N/A