• Molecular NameGlibornuride
  • SynonymNA
  • Weight366.482
  • Drugbank_IDN/A
  • ACS_NO26944-48-9
  • Show 2D model
  • LogP (experiment)N/A
  • LogP (predicted, AB/LogP v2.0)2.85
  • pkaN/A
  • LogD (pH=7, predicted)0.85
  • Solubility (experiment)N/A
  • LogS (predicted, ACD/Labs)(ph=7)-1.72
  • LogSw (predicted, AB/LogsW2.0)0.47
  • Sw (mg/ml) (predicted, ACD/Labs)0.13
  • No.of HBond Donors3
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds3
  • TPSA103.88
  • StatusN/A
  • AdministrationN/A
  • PharmacologyA sulfonylurea.
  • Absorption_value98.0
  • Absorption (description)Readily absorbed after oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein binding95.0
  • Volume of distribution (VD)0.15 to 0.35 L/kg
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmExtensively metabolised by hydroxylation to a series of inactive or almost inactive compounds and by oxidation to a p-carboxy derivative.
  • Half life8 h
  • ExcretionAbout 60 to 70% of a dose is excreted in the urine as metabolites; four hydroxylated derivatives account for about 75% of the urinary material, p-hydroxyglibornuride accounts for about 6%, and p-carboxyglibornuride for about 7%; the remainder of a dose is eliminated in the faeces.
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A