- Molecular NameAmoxicillin
- SynonymAMC; Amoxicilina [INN-Spanish]; Amoxicillin anhydrous; Amoxicillin Trihydrate; Amoxicilline [INN-French]; Amoxicillinum [INN-Latin]; Amoxycillin; Amoxycillin Trihydrate; D-Amoxicillin; p-Hydroxyampicillin
- Weight365.41
- Drugbank_IDDB01060
- ACS_NO26787-78-0
- Show 3D model
- LogP (experiment)-1.99
- LogP (predicted, AB/LogP v2.0)-1.21
- pka2.4, 7.4, 9.6
- LogD (pH=7, predicted)-3.72
- Solubility (experiment)3.48 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-2.61
- LogSw (predicted, AB/LogsW2.0)9.17
- Sw (mg/ml) (predicted, ACD/Labs)0.28
- No.of HBond Donors5
- No.of HBond Acceptors8
- No.of Rotatable Bonds4
- TPSA158.26
- StatusFDA approved
- AdministrationOral, intravenous
- PharmacologyA moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other β-lactam antibiotics. It is also a treatment for cystic acne.
- Absorption_value92.0
- Absorption (description)Amoxicillin is rapidly absorbed after oral administration.
- Caco_2-6.1
- Bioavailability93.0
- Protein binding18.0
- Volume of distribution (VD)0.21 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmLess than 30% biotransformed in liver
- Half life1.7 h
- ExcretionAbout 60% of an oral dose is excreted in the urine as unchanged drug in 6 h and 20% as the inactive metabolite, penicilloic acid, in the same period. After parenteral administration, up to 75% of a dose is excreted in the urine unchanged in 6 h.
- Urinary Excretion86
- Clerance2.6 ml/min/kg.
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)N/A