- Molecular NameHydrocortisone
- Synonym11beta-Hydroxycortisone; 17alpha-Hydroxycorticosterone; Anti-inflammatory hormone; Dihydrocostisone; Hidrocortisona [INN-Spanish]; Hydrocorticosterone; Hydrocortisone Acetate; Hydrocortisone alcohol; Hydrocortisone Base; Hydrocortisone Butyrate; Hydrocortisone free alcohol; Hydrocortisone Sodium Phosphate; Hydrocortisone Valerate; Hydrocortisonum [INN-Latin]; Hydroxycortisone; Idrocortisone [DCIT]
- Weight362.466
- Drugbank_IDDB00741
- ACS_NO50-23-7
- Show 3D model
- LogP (experiment)1.692
- LogP (predicted, AB/LogP v2.0)1.8
- pka5.1
- LogD (pH=7, predicted)1.8
- Solubility (experiment)0.320 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.36
- LogSw (predicted, AB/LogsW2.0)0.14
- Sw (mg/ml) (predicted, ACD/Labs)0.16
- No.of HBond Donors3
- No.of HBond Acceptors5
- No.of Rotatable Bonds2
- TPSA94.83
- StatusFDA approved
- AdministrationOral tablets, intravenously, topical
- PharmacologyA corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland
- Absorption_value91.0
- Absorption (description)Hydrocortisone is readily absorbed after oral administration and through the skin; hydrocortisone acetate is less well absorbed.
- Caco_2-4.6
- BioavailabilityN/A
- Protein binding90.0
- Volume of distribution (VD)0.3 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmIt is metabolised in the liver and other tissues by reduction, hydroxylation, side-chain cleavage, and conjugation with glucuronic acid.
- Half life6~8 h
- ExcretionAbout 90% of a dose is excreted in the urine in 24 h; less than 1% is excreted unchanged, 40% is the 5α- and 5β-forms of tetrahydrocortisol and the 5β-form of tetrahydrocortisone, 17% is a mixture of the 5α- and 5β- and 20α- and 20β-cortols and cortolones, and 6% is 11-hydroxy- and 11-keto-etiocholanolone; most of the metabolites are excreted as glucuronide conjugates; at plasma concentrations of greater than 0.2 mg/L, the amount of unchanged hydrocortisone excreted in the urine is increased.
- Urinary ExcretionN/A
- CleranceN/A
- ToxicitySide effects include inhibition of bone formation, suppression of calcium absorption and delayed wound healing
- LD50 (rat)N/A
- LD50 (mouse)N/A