- Molecular NameLevofloxacin
- SynonymL-Ofloxacin; levofloxacin
- Weight361.373
- Drugbank_IDDB01137
- ACS_NO100986-85-4
- Show 3D model
- LogP (experiment)-0.39
- LogP (predicted, AB/LogP v2.0)0.0
- pka6.0; 8.0
- LogD (pH=7, predicted)-2.02
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-2.63
- LogSw (predicted, AB/LogsW2.0)0.12
- Sw (mg/ml) (predicted, ACD/Labs)0.62
- No.of HBond Donors1
- No.of HBond Acceptors7
- No.of Rotatable Bonds2
- TPSA73.32
- StatusFDA approved
- AdministrationN/A
- PharmacologyA synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class and is used to treat severe or life-threatening bacterial infections or bacterial infections which have failed to respond to other antibiotic classes.
- Absorption_valueN/A
- Absorption (description)Levofloxacin is rapidly absorbed after oral administration with maximum plasma concentrations being reached approx. 1 h after a dose. The absorption of levofloxacin is little affected by the presence of food in the gastro-intestinal tract but administration with a high fat meal may slightly prolong the time to peak concentration. It is widely distributed throughout the body, crosses the placenta and has been detected in breast milk.
- Caco_2N/A
- Bioavailability99.0
- Protein binding31.0
- Volume of distribution (VD)1.36 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmLevofloxacin undergoes limited metabolism
- Half life7 h; may be prolonged in renal impairment.
- ExcretionExcreted mainly as the unchanged drug in urine (80 to 85%) and faeces (2%) within 24 h. The major urinary metabolites are desmethyllevofloxacin and levofloxacin N-oxide, each accounting for only 2% of a dose.
- Urinary Excretion61~87
- Clerance2.52 ml/min/kg
- ToxicitySide effects include disorientation, dizziness, drowsiness, hot and cold flashes, nausea, slurring of speech, swelling and numbness in the face
- LD50 (rat)N/A
- LD50 (mouse)N/A