- Molecular NameFenofibrate
- SynonymFenofibrato [INN-Spanish]; Fenofibratum [INN-Latin]; Fenofibric acid; Finofibrate; FNF
- Weight360.837
- Drugbank_IDDB01039
- ACS_NO49562-28-9
- Show 3D model
- LogP (experiment)5.575
- LogP (predicted, AB/LogP v2.0)5.43
- pkaN/A
- LogD (pH=7, predicted)5.43
- Solubility (experiment)0.25 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-5.2
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors0
- No.of HBond Acceptors4
- No.of Rotatable Bonds7
- TPSA52.6
- StatusFDA approved
- AdministrationN/A
- PharmacologyA drug of the fibrate class.
- Absorption_value90.0
- Absorption (description)Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide
- Caco_2N/A
- BioavailabilityN/A
- Protein binding99.0
- Volume of distribution (VD)0.89 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmFollowing oral administration, fenofibrate is rapidly hydrolyzed by esterases to the active metabolite, fenofibric acid; no unchanged fenofibrate is detected in plasma Fenofibric acid is primarily conjugated with glucuronic acid and then excreted in urine. A small amount of fenofibric acid is reduced at the carbonyl moiety to a benzhydrol metabolite which is, in turn, conjugated with glucuronic acid and excreted in urine. In vivo metabolism data indicate that neither fenofibrate nor fenofibric acid undergo oxidative metabolism (e.g., cytochrome P450) to a significant extent
- Half life20~27 h
- Excretionurine
- Urinary Excretion0.1~10
- Clerance0.45 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)LD50=1600 mg/kg