• Molecular NameMethyclothiazide
  • SynonymMethychlothiazide; Methyclothiazid; Methycyclothiazide; Methylchlorothiazide; Methylclothiazide; Methylcyclothiazide
  • Weight360.242
  • Drugbank_IDDB00232
  • ACS_NO135-07-9
  • Show 3D model
  • LogP (experiment)1.42
  • LogP (predicted, AB/LogP v2.0)0.99
  • pka9.4
  • LogD (pH=7, predicted)0.99
  • Solubility (experiment)0.0598 mg/ml
  • LogS (predicted, ACD/Labs)(ph=7)-3.01
  • LogSw (predicted, AB/LogsW2.0)0.03
  • Sw (mg/ml) (predicted, ACD/Labs)0.35
  • No.of HBond Donors3
  • No.of HBond Acceptors7
  • No.of Rotatable Bonds2
  • TPSA126.33
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA diuretic.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed following oral administration.
  • Caco_2N/A
  • BioavailabilityN/A
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmMethyclothiazide is slowly eliminated by the kidneys as intact drug but primarily as an inactive metabolite.
  • Half lifeN/A
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicitySymptoms of overdosage include electrolyte imbalance and signs of potassium deficiency such as confusion, dizziness, muscular weakness, and gastrointestinal disturbances.
  • LD50 (rat)LD50>4000 mg/kg
  • LD50 (mouse)N/A