- Molecular NamePrednisone
- SynonymDehydrocortisone; PRD; Prednisona [INN-Spanish]; Prednisonum [INN-Latin]
- Weight358.434
- Drugbank_IDDB00635
- ACS_NO53-03-2
- Show 3D model
- LogP (experiment)1.5
- LogP (predicted, AB/LogP v2.0)1.66
- pkaN/A
- LogD (pH=7, predicted)1.66
- Solubility (experiment)0.119 mg/ml
- LogS (predicted, ACD/Labs)(ph=7)-3.56
- LogSw (predicted, AB/LogsW2.0)0.24
- Sw (mg/ml) (predicted, ACD/Labs)0.1
- No.of HBond Donors2
- No.of HBond Acceptors5
- No.of Rotatable Bonds2
- TPSA91.67
- StatusFDA approved
- AdministrationOral, Nasal, Rectal, Injection, IV
- PharmacologyA synthetic corticosteroid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. It is used to treat certain inflammatory diseases and (at higher doses) cancers, but has significant adverse effects.
- Absorption_value95.0
- Absorption (description)Readily absorbed from the gastrointestinal tract.
- Caco_2N/A
- Bioavailability80.0
- Protein binding75.0
- Volume of distribution (VD)0.97 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmPrednisolone (liver)
- Half life2~3 h
- ExcretionRenal
- Urinary Excretion3
- Clerance3.6 ml/min/kg
- ToxicityN/A
- LD50 (rat)N/A
- LD50 (mouse)LD50>1500