- Molecular NameCinacalcet
- SynonymNA
- Weight357.419
- Drugbank_IDDB01012
- ACS_NO226256-56-0
- Show 2D model
- LogP (experiment)6.791
- LogP (predicted, AB/LogP v2.0)5.99
- pkaN/A
- LogD (pH=7, predicted)3.62
- Solubility (experiment)N/A
- LogS (predicted, ACD/Labs)(ph=7)-3.31
- LogSw (predicted, AB/LogsW2.0)0.0
- Sw (mg/ml) (predicted, ACD/Labs)0.0
- No.of HBond Donors1
- No.of HBond Acceptors1
- No.of Rotatable Bonds7
- TPSA12.03
- StatusFDA approved
- AdministrationN/A
- PharmacologyA drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues.
- Absorption_valueN/A
- Absorption (description)Rapidly absorbed following oral administration.
- Caco_2N/A
- Bioavailability20.0
- Protein binding95.0
- Volume of distribution (VD)17.6 L/kg
- Blood/Plasma Partitioning ratio (D_blood)N/A
- MetabollsmHepatic (CYP3A4-, CYP2D6- and CYP1A2-mediated)
- Half life34 h
- ExcretionRenal (80%) and fecal (15%)
- Urinary ExcretionNegligible
- Clerance18 ml/min/kg
- ToxicityDoses titrated up to 300 mg once daily have been safely administered to patients on dialysis. Overdosage of cinacalcet may lead to hypocalcemia.
- LD50 (rat)N/A
- LD50 (mouse)N/A