• Molecular NameYohimbine
  • SynonymYohimbin
  • Weight356.422
  • Drugbank_IDDB01392
  • ACS_NO146-48-5
  • Show 2D model
  • LogP (experiment)2.7
  • LogP (predicted, AB/LogP v2.0)1.93
  • pkaN/A
  • LogD (pH=7, predicted)1.84
  • Solubility (experiment)Slightly soluble
  • LogS (predicted, ACD/Labs)(ph=7)-1.35
  • LogSw (predicted, AB/LogsW2.0)0.3
  • Sw (mg/ml) (predicted, ACD/Labs)0.9
  • No.of HBond Donors2
  • No.of HBond Acceptors6
  • No.of Rotatable Bonds2
  • TPSA74.79
  • StatusFDA approved
  • AdministrationN/A
  • PharmacologyA psychoactive drug of the tryptamine chemical class with stimulant and aphrodisiac effects.
  • Absorption_valueN/A
  • Absorption (description)Rapidly absorbed following oral administration. Bioavailability is highly variable, ranging from 7 to 87% (mean 33%).
  • Caco_2N/A
  • Bioavailability33.0
  • Protein bindingN/A
  • Volume of distribution (VD)N/A
  • Blood/Plasma Partitioning ratio (D_blood)N/A
  • MetabollsmYohimbine appears to undergo extensive metabolism in an organ of high flow such as the liver or kidney, however, the precise metabolic fate of yohimbine has not been fully determined.
  • Half life0.6 h
  • ExcretionN/A
  • Urinary ExcretionN/A
  • CleranceN/A
  • ToxicityN/A
  • LD50 (rat)N/A
  • LD50 (mouse)N/A